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Tirzepatide is a dual-action peptide that stimulates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors, which may explain why some patients experience faster weight loss with tirzepatide compared to semaglutide alone

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[DOI] [PubMed] [Google Scholar] [39].Singh P, Zeng X, Chen X, Yang Y, Chen Y, Cui S, Carrier A, Oakes K, Luan T, Zhang X, Quantitation of polymeric-microneedle-delivered HA15 in tissues using liquid chromatography-tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis 185 (2020) 113230